Wakunaga Seiyaku Kabushiki Kaisha

Fujisawa Pharmaceutical Company, Ltd.

Masaharu Yokomoto

Satoshi Inoue

Akira Yazaki

Terukage Hirata

Nobuya Sakae

Yasuhiro Kuramoto

Norihiro Hayashi

Kouji Nishimura

Shunso Hatono

Jun Nomiyama

Hirotaka Amano

Yuzo Hirao

Takashi Yatsunami

Koichi Tamura

Masayasu Okuhira

Shunsou Hatono

Shuichiro Noda

Hitoshi Yamamoto

Process for producing N-biphenylmethylthiadiazoline derivative or salt

Process for producing tetrazolylated biphenylmethane derivatives

This invention relates to a biphenylmethane derivative represented by the formula (1): ##STR1## wherein A represents a group ##STR2## in which R.sup.1, X, Y, Z and B are as defined in the Specification. The compounds have potent angiotensin II antagonist activity and anti-hypertensive effect. They have therapeutic utility for circulatory diseases such as hypertension, heart diseases and cerebral apoplexy.

Biphenylmethane derivatives and pharmaceuticals containing the same

A tricyclic compound represented by the general formula (1) and salts thereof are disclosed. ##STR1## A method for producing the tricyclic compound and salts thereof, and an antimicrobial agent containing the tricyclic compound and salts thereof as an active ingredient are also disclosed.

Tricyclic compound or salts thereof, method for producing the same and

A tricyclic compound represented by the general formula (1) and salts thereof. ##STR1## A method for producing the tricyclic compound and salts thereof, and an antimicrobial agent containing the tricyclic compound and salts thereof as an active ingredient are also disclosed.

Isoindoline derivatives represented by the formula (I) and their salts are disclosed. ##STR1## There are many varieties for the compound depending on the types of residues R.sup.1 -R.sup.9 and X. The compounds can be prepared from quinoline derivatives of the formula (II) and an isoindoline derivatives of the formula (III). The compounds of formula (I) and their salts have excellent antibacterial activities against both gram positive and gram negative microorganisms. They can be used as a medicine, an agrichemical, and a food preservative.

Isoindoline derivative

A bile acid derivative of the following formula (I): ##STR1## wherein: X is a halogen atom; R.sub.1 is a hydrogen atom or a lower alkyl group; Y is ##STR2## (wherein n is an integer of from 0 to 5); each of R.sub.2 and R.sub.3 is a hydrogen atom or a hydroxyl group; R.sub.4 is a hydroxyl group, lower alkoxyl group, ##STR3## (wherein R.sub.5 is a hydrogen atom or a lower alkoxy group, R.sub.6 is a carboxyl group, benzyloxycarbonyl group or sulfonyl group, or a salt thereof, and m is an integer of from 1 to 4); the intermittent line, . . . , is an .alpha.-bond; and the wavy line,  , is an .alpha.- or .beta.-bond, and a salt thereof, and a process for production thereof. This bile acid derivative has carcinostatic activity and yet is of low toxicity. Accordingly, this compound can be used as a carcinostatic agent.

Bile acid derivatives, their salts and production thereof

Growing community of inventors

Hiroshima, Japan

Masaharu Yokomoto