Mitsui Petrochemical Industries, Ltd.

Mitsui Pharmaceuticals, Inc.

Masaharu Ishiguro

Noriaki Kihara

Akira Awaya

Kazutoshi Horikomi

Ikuo Tomino

Akira Mizuchi

Takumi Kitahara

Junichi Imuta

Keiichi Yokoyama

Daisuke Fukuoka

Takuo Nakano

Teruaki Mukaiyama

Ken Ikeda

Takashi Tashiro

Joji Kamiya

Hiroaki Tan

Hisaya Miki

Katsuya Takahashi

Nobuya Hirokane

Masaaki Ishii

Tadayuki Sasaki

Takeshi Ishitoku

Kanji Yoshihara

Yuichiro Kokubun

Pyrimidine compound and pharmaceutically acceptable salts thereof

Amine represented by the following formula (1), or their acid addition salts or their quaternary ammonium salts. ##STR1## The amines of formula (1) or their pharmaceutically acceptable acid addition salts or quaternary ammonium salts are useful for the treatment and prevention of heart diseases of animals, particularly arrhythima, myocardial infarction, angina pectoris and heart failure and psychoneurological diseases.

Coumaran group containing amine compounds and their acid addition salts

Process for preparing polyalkyl-2-alkoxy-7-hydroxychroman derivative of the general formula (V): ##STR1## wherein R.sup.1 denotes lower primary alkyl, R.sup.2 denotes hydrogen or lower primary alkyl and R.sup.3 denotes loweralkyl, by reacting resorcin with either an aliphatic ketone of the general formula (I): ##STR2## wherein R.sup.1 and R.sup.2 are as defined above, and an alcohol of the formula (II):

Process for preparing polyalkyl-2-alkoxy-7-hydroxychroman derivatives

A method of oxidizing secondary alkyl substituted naphthalenes with molecular oxygen in a liquid phase to hydroperoxides, carbinols or mixtures of these, which comprises: oxidizing the secondary alkyl substituted naphthalenes in the presence of an aromatic hydrocarbon having a fused ring which contains at least one methylene group therein in amounts of not more than about 1000 ppm based on the secondary alkyl substituted napththalene used. A process of producing isopropylnaphthols is also disclosed, which comprises: oxidizing diisopropylnaphthalenes with molecular oxygen in a liquid phase to diisopropylnaphthalene monohydroperoxides in the presence of (a) either an aromatic hydrocarbon having a fused ring which contains at least one methylene group therein, or a paladium catalyst soluble in the reaction mixture, and (b) an organic polar compound such as acetonitrile; and then acid-decomposing the diisopropylnaphthalene monohydroperoxide to the isopropylnaphthol.

Method of oxidizing secondary alkyl substituted naphtalenes and a

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Yamaguchi, Japan

Masaharu Ishiguro