Sankyo Company, Limited

Masaharu Fukami

Mitsuru Kataoka

Tomihisa Yokoyama

Hiroyoshi Horikoshi

Toshihiko Fujiwara

Atsusuke Terada

Kazue Hasegawa

Insulin sensitizers, especially thiazolidinedione compounds, such as troglitazone, are useful for the treatment and prevention of pancreatitis.

Treatment and prophylaxis of pancreatitis

Pharmaceutical compositions and methods for treatment of eye disorders employ ocular hypotensive compounds of the formula (I) ##STR1## wherein R.sup.1 is selected from hydrogen, C.sub.1 -C.sub.6 alkyl, and C.sub.1 -C.sub.6 alkoxy; each R.sup.2 is selected from hydrogen, C.sub.1 -C.sub.6 alkyl, halogen, nitro or carboxy; R.sup.3 is selected from amino, mono-substituted amino, and di-substituted amino; A and B each represents C.sub.1 -C.sub.6 alkylene, X represents --NH-- or --CH.sub.2 -- and n is 1, 2 or 3; and pharmaceutically acceptable salts or esters thereof.

Ocular hypotensive agents

Pharmaceutical compositions and methods for treatment of eye disorders employ ocular hypotensive compounds of the formula (I); ##STR1## (wherein: R.sup.1 is selected from hydrogen, C.sub.1 -C.sub.6 alkyl, and C.sub.1 -C.sub.6 alkoxy;

Occular hypotensive agents

Compounds of formula: ##STR1## (wherein R represents hydrogen or methyl, &gt;A--B-- represents a &gt;CH--CH.sub.2 -- or &gt;C.dbd.CH-- group; &gt;C--Z represents a &gt;C.dbd.O or &gt;CH--OH group; and n represents 1 or 2) and ophthalmically acceptable salts and esters thereof are useful as ophthalmic anti-inflammatory agents.

Growing community of inventors

Tokyo, Japan

Masaharu Fukami