Fujirebio Kabushiki Kaisha

Cambwick Healthcare K.k.

Seikagaku Corporation

Masaharu Dozen

Masahiro Shibata

Nobuo Kobayashi

Tsuneo Koji

Akihiko Hosoda

Akihiro Sekine

Yuki Tada

Daijiro Okihara

Keisuke Hirasawa

Naoko Tanabe

Naoko Koji

A DC power supplyis connected with the DC-type high voltage generatorthat boosts the power supply. A negative output terminaland a positive output terminalof the generatorare respectively connected to a cathode electrodeand an anode electrode. A dielectric sheetwith appropriate relative permittivity and certain range of volume resistivity is closely attached on the cathode electrode surface opposed to the anode electrode. The cathode electrodetogether with the dielectric sheetconstitutes a DC-type dielectric barrier electrode. The power supplyand the generatorare disposed on an upper surface of a belt-type attachment, and the discharge electrodeand the anode electrodeare disposed on the lower surface thereof. The electrodesandbecome opposed to each other upon wrapping the attachmentaround the affected part of a subject.

Electron irradiation apparatus of DC-type dielectric barrier discharge and electrical therapeutic apparatus

A cyclic amide derivative of formula (I): ##STR1## wherein R.sup.1 represents a substituted alkyl group, a substituted alkenyl group, a substituted amino group, a substituted alkoxyl group, a substituted alkylthio group, a substituted carbamoyl group, a substituted sulfonamide group or a substituted amide group; the ring A represents a saturated cyclic alkyl group with 5 to 7 carbon atoms or a hetero-atom-containing saturated heterocyclic group with 3 to 6 carbon atoms; R.sup.2 represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted heterocyclic group; R.sup.3 represents a hydrogen atom, a group represented by the general formula R.sup.4 O-- or a group represented by the general formula R.sup.5 (R.sup.6)N-- wherein R.sup.4 represents hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted heterocyclic group; R.sup.5 and R.sup.6 may be the same or different and each represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted heterocyclic group. The cyclic amide derivative of formula (I) have a strong and selective inhibitory action of a cathepsin K and a clinical efficacy when administered orally.

Cyclic amide derivatives

Growing community of inventors

Tokyo, Japan

Masaharu Dozen