Ss Pharmaceutical Co., Ltd.

Masago Ishikawa

Susumu Sato

Hideaki Matsuda

Hiroyuki Mizuno

Haruyoshi Honda

Fujiko Konno

Terumitsu Kaihoh

Tomomi Okada

Yoshinori Takahashi

Disclosed herein is a substituted piperidine derivative represented by the following general formula (1):

Substituted piperidine derivative for treating urinary disturbance

Disclosed herein is a substituted piperidine derivative represented by the following general formula (1): ##STR1## wherein R.sup.1 means an aryl or heteroaryl group which may have at least one substituent, R.sup.2 denotes an alkyl, alkenyl or aralkyl group, R.sup.3 stands for a hydrogen atom or an alkyl group, and R.sup.4 is a hydrogen atom, an alkyl group, or an aryl, heteroaryl, aralkyl, aralkenyl or heteroaralkyl group which may have at least one substituent, or a salt thereof. A medicine including this compound is also disclosed. The compound has excellent anticholinergic effect and calcium antagonism and inhibits reflex bladder contraction and is hence useful for prophylaxis of and treatment for a urinary disturbance such as pollakiuria.

Substituted piperidine derivative and medicine comprising the same

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Shisui-machi, Japan

Masago Ishikawa