Kotobuki Seiyaku Co. Ltd.

Masafumi Yasunami

Tsuyoshi Tomiyama

Akira Tomiyama

Takashi Yanagisawa

Kahei Takase

Shuuichi Wakabayashi

Masayuki Yokota

Rei Koyama

Hiromi Hayashi

A series of new azulene analogues are disclosed, which are represented by the following formula: ##STR1## wherein: R.sub.1 is --COOH, --COOR.sub.4 (R.sub.4 represents a lower alkyl), --CH.dbd.CH--COOH, --CH.sub.2 --COOH or --SO.sub.3 H;

Azulene derivatives as thromboxane A.sub.2 and prostaglandin

A new series of azulene derivatives are disclosed. These compounds are stable to light and heat and are useful as anti-ulcerative and anti-inflammatory agents. Such compounds can be synthesized by reacting 2H-cyclohepta(b) furan-2-one or its derivative substituted by a lower alkyl with a suitable enamine derived from a corresponding aldehyde or ketone, and then sulfonating the compound resulting from said reaction.

Azulene derivatives, processes of their synthesis and their uses as

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Sendai, Japan

Masafumi Yasunami