Yoshitomi Pharmaceutical Industries, Ltd.

Masafumi Arita

Tetsuya Tahara

Hiroyuki Satoh

Keiji Yamagami

Tsuyoshi Kuroda

Tadamasa Saitoh

Masanori Minoguchi

Yukio Hoshino

Masayoshi Uehata

Hirotsugu Komatsu

Mitsuharu Sano

Yoshinao Tsuda

Hiroyuki Sato

Toshio Hamasaki

Tatsumi Tsumagari

Takenori Kenjo

Yoshitaka Fukumasu

Hirofumi Okuda

Tadamasa Saito

Benzamide compounds of the formula ##STR1## wherein each symbol is defined in the specification, isomers thereof and pharmaceutically acceptable acid addition salts thereof. Pharmaceutical compositions comprising a therapeutically effective amount of this compound and a pharamaceutically acceptable additive, and therapeutic agents for hypertension, therapeutic agents for angina pectoris, therapeutic agent for asthma, therapeutic agents for renal and peripheral circulatory disturbances and inhibitor of cerebral vasospasm, which comprise this compound. The compound of the present invention has strong smooth muscle relaxing action, and shows hypertensive action and cerebral.cndot.coronary vasodilating action like conventional calcium antagonists, as well as long-lasting renal and peripheral circulation improving action. Unlike calcium antagonists, it permits oral administration to suppress vascular contraction caused by various agonists, and is useful as a strong and long-acting agent for prophylaxis and treatment of circulatory diseases in coronary, cerebral, renal and peripheral arteries, as a therapeutic agent for hypertension, angina pectoris, and renal and peripheral circulation disorder, an inhibitor of cerebral vasospasm and the like. Moreover, the compound of the present invention is useful as a therapeutic agent for asthma.

Benzamide compounds and pharmaceutical use thereof

4-amino(alkyl)cyclohexane-1-carboxamide compound and use thereof

3,4-dihydrothieno[2,3-d]pyrimidine compounds and their pharmaceutical use

4-amino-tetrahydro-2-naphthoic acid derivatives

Indeno(1,2-b)pyrrole derivatives

1,4-Methano-2-benzazepine derivatives useful as cerebal

4,4-Diphenylcyclohexylpiperidine compounds and their analogs of the formula: ##STR1## wherein the dotted line in Ring A indicates an optional bond; R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently a hydrogen atom, a halogen atom, a trifluoromethyl group or a lower alkyl group; n is 1 or 2; m is 0 or 1; and Am is a piperidino group of the formula: ##STR2## where R.sup.5 and R.sup.6 are independently a hydrogen atom, a halogen atom, a trifluoromethyl group or a lower alkyl group, and the dotted line in Ring B indicates an optional bond; And pharmaceutically acceptable salts thereof are disclosed. They exhibit potent and long-lasting psychotropic effects.

4,4-Diphenylcycloalkylpiperidines and psychotropic compositions thereof

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Chikujo-gun, Japan

Masafumi Arita