Shionogi Company Limited

Masaaki Uenaka

Yasuyuki Kawanishi

Munenori Matsuura

Susumu Takada

Masahiko Nagai

Nobuo Chomei

Naotake Kobayashi

Kyozo Kawata

Yoshinori Hamada

Takeshi Endoh

Kouichi Noguchi

Fumihiko Matsubara

Teruo Sakata

Isamu Yamada

Yasuyuki Hozumi

Takashi Ohya

Tadafumi Komurasaki

The present invention relates to a process for preparing a compound of the formula: wherein Ris lower alkyl, Ris hydrogen or lower alkyl, and Z is optionally substituted lower alkyl, optionally substituted lower alkenly, optionally substituted amino, optionally substituted lower alkoxy, optionally substituted carbocyclyl or optionally substituted heterocyclyl.

Process for trans-4-amino-1-cyclohexanecarboxylic acid derivatives

The disclosed invention relates to a solvate of the compound (I) of the formula: or a crystal thereof.

Crystal of intermediate for carbapenem

A process for the preparation of Compound (I) comprising reacting Compound (II) with a base in an aprotic solvent, which is represented by the following scheme: wherein Rand Rare each independently lower alkyl.

Process for trans-4-amino-1-cyclohexanecarboxilic acid derivatives

Process for producing trans-4-amino-1-cyclohexanecarboxilic acid derivative

The present invention provides a process of a compound of the formula (I): wherein R is heteroaryl or the like, ring A is a heteroalicyclic group or the like comprising reacting a compound of the formula (II): wherein Hal is halogen and the other symbols are the same as the above, in the presence of a sulfinic acid salt and further in the presence of an acid or a salt with an organic base, and a novel crystal form of 2-(3-isoxazolyl)-3,6,7,9-tetrahydroimidazo[4,5-d]pyrano[4,3-b]pyridine phosphate monohydrate.

Synthetic process and crystal form of condensed imidazopyridine derivatives

Industrial and commercial processes for the preparation of 2-acyl-5-benzylfuran derivatives, 1,2,4-triazole-3-carboxylic acid ester derivatives or propenone derivatives having an anti-HIV activity; and useful crystals of the derivatives. A deblocking: (III-2), (IV-10), (VI-1), wherein R , R and R are each independently hydrogen or the like; A is CR or N; R is hydrogen or the like; Q is a protecting group; and L is a leaving group.

Processes for the preparation of substituted propenone derivatives

Process for producing 4-thiazolylmethyl derivative

A process for the preparation of 3-isoxazolecarboxlic acid which is an intermediate for prepearing useful compounds is provided, said process being characterized in that a compound of formula (I) is reacted with hydroxylamine to obtain a compound of formula (II), and the compound thus obtained is treated with an alkali: ##STR1## wherein R.sup.1 is a lower alkyl, R.sup.2 is a carboxy protecting group, X is a halogen atom, and Y is a hydrogen atom, or X and Y together may form a single bond.

Process for the preparation of 3-isoxazolecarboxylic acid

Method for preparing benzoic acid derivatives

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Amagasaki, Japan

Masaaki Uenaka