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Meiji Seika Kaisha, Ltd.

Maiji Seika Kaisha Ltd.

Masaaki Takahashi

Osamu Sakanaka

Makoto Ohyama

Katsuharau Iinuma

Yashushi Murai

Yoshiya Shigematsu

Peter Jeschke

Norbert Mencke

Achim Harder

Gerhard Bonse

Yasushi Murai

Katsuharu Iinuma

Yumiko Okada

Maki Matsumoto

Novel derivatives of PF1022 substance, which are cyclodepsipeptides represented by the general formula (I) shown below or their salts are useful as anthelmintic agent for prevention or treatment of parasitic infections.

Derivatives of cyclodepsipeptide PF1022 substance

Known cyclic depsipeptides which are PF 1022F substance and PF 1022H substance, as well as a novel cyclic depsipeptide, PF 1022G substance, are now prepared simultaneously by cultivating a fungal strain capable of producing PF 1022F substance, PF 1022G substance and PF 1022H substance represented by the known PF 1022 strain (deposited under FERM BP-2671) which is a kind of fungus belonging to asporous imperfect fungi (the order Agonomycetales) and is presumable to belong to the genus Xylaria or the genus Rosellinia in the family Xylariaceae. The PF 1022G substance has the formula: ##STR1##

Cyclic depsipeptide PF 1022G

Preparation of cyclic depsipeptide compounds and a novel cyclic

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Odawara, Japan

Masaaki Takahashi