Toray Industries, Inc.

Masaaki Shimagaki

Yoshiyuki Ueno

Kazuo Teramoto

Masahiro Osabe

Fumiaki Fukui

Takeshi Sonoda

Tatsuya Kishikawa

Koji Sugita

Koji Watanabe

Yuji Ueda

Toshio Yoshioka

Takeo Matsunase

Shigehisa Wada

Yasufumi Yamamura

Hisashi Minamiguchi

Shigenori Tanaka

Tomoya Hayashi

Yoshiki Yamamoto

Katsuhisa Sato

Takeshige Oozeki

Masami Ohta

Ema Iwanaga

A polysulfone-based hollow fiber membrane that purifies blood preparations, including a hydrophilic polymer on a surface thereof which contacts the blood preparation, wherein an abundance ratio of the hydrophilic polymer is from 40 to 60% by mass, and porosity at the surface is 8 to 30%.

Polysulfone-based hollow fiber membrane and hollow fiber membrane module that purifies blood preparations

A method of producing a platelet solution replaced with an artificial preservation solution includes a filtering step of carrying out cross-flow filtration of a platelet solution under the conditions of Formula (1) at an inlet wall shear rate of 25 to 1500 susing a separation membrane whose surface which contacts with the platelet solution has an average pore size of not less than 0.1 &#x3bc;m and less than 2.0 &#x3bc;m, thereby obtaining a concentrated platelet solution; and a mixing step of mixing the concentrated platelet solution with an artificial preservation solution to obtain the platelet solution replaced with an artificial preservation solution:1.0&#xd7;10&#x3c;()/(&#x3b3;&#xd7;&#x3bc;)&#x2266;2.5&#xd7;10(platelets/(hr&#xb7;m&#xb7;Pa))&#x2003;&#x2003;(1)

Method of preparing platelet solution replaced with artificial preservation solution

An adsorbent for immunosuppressive substance, which can adsorb an excessive immunosuppressive substance directly from a body fluid, can carry out extracorporeal perfusion safely and can be utilized in treatment of cancer. The excessive immunosuppressive substance may be involved in growth of cancer cells. The adsorbent for immunosuppressive substance includes a water-insoluble carrier and a hydrophilic amino group immobilized to the water-insoluble carrier. An extracorporeal perfusion column contains the adsorbent of the invention. A method for treating cancer carries out extracorporeal perfusion using the extracorporeal perfusion column. A method of adsorbing the transforming growth factor &#x3b2; which is combined with another protein, includes adsorbing the transforming growth factor &#x3b2; and protein on an adsorbent containing a water-insoluble carrier to which quaternary ammonium groups each having 3 to 18 carbon atoms per one nitrogen atom are attached, and having a specific surface area of 0.1 mor more per gram.

Method of adsorbing transforming growth factor &#x3b2;

The present invention provides an absorbent which can remove cells present in blood including activated leukocytes such as granulocytes and monocytes, and cancer cells as well as can remove cytokines which facilitate the activation of the remaining cells, and further has no concern for pressure loss and has high configuration stability. That is, the present invention provides an absorbent which absorbs the granulocytes and the monocytes in blood, an absorbent for cancer therapy which absorbs an immunosuppressive protein and an absorbent having a bilayer structure of a net and a nonwoven fabric, having a zeta potential of &#x2212;20 mV or more, as well as a blood circulation column containing any of the absorbents filled therein.

Absorbent and column for extracorporeal circulation

A polishing pad characterized by having a mechanism for supplying water to the plane of the polishing pad in contact with the article to be polished, in particular, in case the mechanism comprises a domain structure having an area of 1&#xd7;10mor smaller, reduces the generation of scratches and the dust adhesion on the surface of the article to be polished, while increasing polishing rate at low dishing and erosion; hence, the product is applicable to the field of surface polishing of semiconductor thin films.

Polishing pad, and method and apparatus for polishing

Respective hollow fiber membranes suitable for use in removing undesired contaminants from blood, in particular in an artificial kidney, have:

Polysulfone hollow fiber semipermeable membrane

Growing community of inventors

Urayasu, Japan

Masaaki Shimagaki