Ube Industries, Inc.

Masaaki Matoyama

Noriaki Iwase

Shigeyuki Kono

Tomio Kimura

Shigeru Ushiyama

Hiroshi Nishida

Eiji Okanari

Makoto Okudo

Masaaki Ito

Hirofumi Matsunaga

Kenji Nishikawa

Masayuki Tanaka

Yusuke Shiraishi

Masahiro Kojima

Satoshi Umezaki

Hayato Nishiyama

Hidetoshi Sunamoto

Yasuhiro Aga

Kouhei Nodu

Yusuke Tateno

Sayaka Ogi

Takashi Matsushita

Kazuhiro Onuma

Hiroto Akaza

Takashi Fukuda

Toshiyuki Akiyama

Shinji Suzuki

Methods of producing a compound represented by formula (I) or a pharmacologically acceptable salt thereof include: wherein Lis an optionally substituted Calkylene group or the like, Lis a single bond or the like, Lis a single bond or the like, R, R, and Rare each independently an optionally substituted Calkyl group or the like, Ris a hydrogen atom or the like, and Ris a hydrogen atom or the like.

Substituted dihydropyrrolopyrazole compound

A novel &#x3b1;-halogen-substituted thiophene compound or a pharmacologically acceptable salt thereof, which has a potent LPA receptor-antagonist activity and is useful as a medicament is provided. A compound represented by the general formula (I) wherein A represents, a phenyl ring, a thiophene ring, or an isothiazole ring; Ris the same or different, and represents a halogen atom, or a C-Calkyl group; Rrepresents a hydrogen atom, or a C-Calkyl group; p represents an integer of 0 to 5; V represents CRwherein Rrepresents a hydrogen atom, an amino group, a nitro group, or a C-Calkoxy group, or V represents a nitrogen atom; and X represents a halogen atom, or a salt thereof.

Halogen-substituted heterocyclic compound

Provided is a compound represented by formula (I) or a pharmacologically acceptable salt thereof: wherein Lis an optionally substituted Calkylene group or the like, Lis a single bond or the like, Lis a single bond or the like, R, R, and Rare each independently an optionally substituted Calkyl group or the like, Ris a hydrogen atom or the like, and Ris a hydrogen atom or the like.

The invention provides a novel &#x3b1;-halogen-substituted thiophene compound salt that has a potent LPA receptor antagonistic action and is useful as a medicament. The salt is represented by the general formula (I):  

Halogen-substituted heterocyclic compound salt

A novel &#x3b1;-halogen-substituted thiophene compound or a pharmacologically acceptable salt thereof, which has a potent LPA receptor-antagonist activity and is useful as a medicament is provided.

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Ube, Japan

Masaaki Matoyama