Koichi Shudo

Meiji Seika Kaisha, Ltd.

Masaaki Izumi

Yasuo Sato

Satoshi Yoshida

Hiroshi Murakami

Seiji Shibahara

Katsuyoshi Iwamatsu

Fukio Konno

Shigeharu Inoye

Sojiro Shiokawa

Tomoko Ito

Tetsutaro Niisato

Kazuko Amano

A compound represented by the following general formula (1): wherein Rrepresents a halogen atom, Rrepresents hydrogen atom or a lower alkyl group, and Rrepresents hydrogen atom, a lower alkyl group, a lower alkoxyl group, a hydroxy lower alkyl group, a halogen atom, or a substituted or unsubstituted amino group, wherein a substituent on the amino group is selected from the group consisting of a lower alkyl group, a lower alkenyl group, a lower alkylcarbonyl group, and an amino protective group, or a salt thereof. The compound of the present invention or a salt thereof is useful as an active ingredient of medicaments for preventive and/or therapeutic treatment of conditions of irritable bowel syndrome and digestive tract functional disorder, or condition of diarrhea.

Benzoxazole derivatives and drugs containing the same as the active ingredient

A benzoxazole derivative of the formula (1) or (2) which has an alicyclic diamine group at the 2-position: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, X.sup.-, m and n are defined herein. The compound shows excellent 5-HT.sub.3 receptor antagonism and is useful as an antiemetic agent, a peristalsis controlling agent, an analgesic agent, an antianxiety agent and a schizophrenia treating agent.

Benzoxazole derivatives

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Yokohama, Japan

Masaaki Izumi