Ube Industries, Inc.

Ube Corporation

Masaaki Ito

Tomio Kimura

Shigeru Ushiyama

Noriaki Iwase

Hiroshi Nishida

Shigeyuki Kono

Eiji Okanari

Makoto Okudo

Masaaki Matoyama

Hirofumi Matsunaga

Kenji Nishikawa

Ken-ichi Komori

Yusuke Shiraishi

Tetsuo Kawaguchi

Koji Ito

Masahiro Kojima

Yasunori Tokunaga

Hiroyoshi Kawada

Masaru Shinohara

Haruka Yamada

Akishi Ninomiya

The present invention provides a compound of general formula (I) (wherein X is as described in the present description and claims), or a pharmacologically acceptable salt thereof, and a pharmaceutical composition containing that compound.

Substituted guanidine compounds

The present invention provides a compound of general formula (I) (wherein, R, X, p and q are as described in the present description and claims), or a pharmacologically acceptable salt thereof, and a pharmaceutical composition containing that compound.

Substituted guanidine derivatives

A novel &#x3b1;-halogen-substituted thiophene compound or a pharmacologically acceptable salt thereof, which has a potent LPA receptor-antagonist activity and is useful as a medicament is provided. A compound represented by the general formula (I) wherein A represents, a phenyl ring, a thiophene ring, or an isothiazole ring; Ris the same or different, and represents a halogen atom, or a C-Calkyl group; Rrepresents a hydrogen atom, or a C-Calkyl group; p represents an integer of 0 to 5; V represents CRwherein Rrepresents a hydrogen atom, an amino group, a nitro group, or a C-Calkoxy group, or V represents a nitrogen atom; and X represents a halogen atom, or a salt thereof.

Halogen-substituted heterocyclic compound

The invention provides a novel &#x3b1;-halogen-substituted thiophene compound salt that has a potent LPA receptor antagonistic action and is useful as a medicament. The salt is represented by the general formula (I):  

Halogen-substituted heterocyclic compound salt

A novel &#x3b1;-halogen-substituted thiophene compound or a pharmacologically acceptable salt thereof, which has a potent LPA receptor-antagonist activity and is useful as a medicament is provided.

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Ube, Japan

Masaaki Ito