Nippon Chemiphar Co., Ltd.

Honda Giken Kogyo Kabushiki Kaisha

Kinki University

Masaaki Hirose

Isao Ooi

Hiroshi Nagase

Eriko Nakata

Hideaki Fujii

Kohei Hayashida

Akiyoshi Saitoh

Atsushi Kurauchi

Atsufumi Kawabata

Katsumi Kanasugi

Tsuyoshi Endo

Hiroto Tanaka

Toru Ogawa

Yuzo Mogi

A method for therapeutic treatment of pain-associated anxiety or depression in a mammalian subject in need thereof, that includes administering to the subject an effective amount of a pharmaceutical composition containing a morphinan derivative that exhibits an opioid δ receptor agonist activity.

Use of morphinan derivatives for treatment of opioid delta receptor agonist-related disease

A morphinan derivative represented by the following general formula (I): wherein Rrepresents hydrogen, Calkyl, cycloalkylalkyl where the cycloalkyl moiety has 3 to 6 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms, etc.; Rrepresents heterocyclic ring containing 1 to 4 heteroatoms selected from N, O and S and at least one carbon atom as ring-constituting atoms, containing at least one set of adjacent ring-constituting atoms bound by a double bond, and further substituted with at least one oxo group; Y binds to a carbon atom as a ring-constituting atom of R; R, R, and Rrepresent hydrogen, hydroxy, etc.; Rand Rrepresent hydrogen, etc.; Rand Rrepresent hydrogen, etc.; Rand R, which are the same or different, represent hydrogen, etc.; X represents O or CH; and Y represents C(&#x2550;O)); a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof is used as an anxiolytic drug, antidepressant, etc.

Morphinan derivative

The present invention relates to a pharmaceutical composition comprising a morphinan derivative that exhibits an opioid &#x3b4; receptor agonist activity. By administering the pharmaceutical composition provided by the present invention, opioid &#x3b4; receptor-related diseases (for example, headache) can be treated or prevented.

Use of morphinan derivative for therapeutic treatment of opioid delta receptor agonist-related disease

A compound represented by the following General Formula (I), a tautomer or a stereoisomer of the compound, a pharmaceutically acceptable salt thereof, or a solvate thereof, is used as a voltage-dependent T-type calcium channel blocker: 

Voltage-dependent t-type calcium channel blocker

A morphinan derivative represented by the following general formula (I): wherein Rrepresents hydrogen, Calkyl, cycloalkylalkyl where the cycloalkyl moiety has 3 to 6 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms, etc.; Rrepresents heterocyclic ring containing 1 to 4 heteroatoms selected from N, O and S and at least one carbon atom as ring-constituting atoms, containing at least one set of adjacent ring-constituting atoms bound by a double bond, and further substituted with at least one oxo group; Y binds to a carbon atom as a ring-constituting atom of R; R, R, and Rrepresent hydrogen, hydroxy, etc.; Rand Rrepresent hydrogen, etc.; Rand Rrepresent hydrogen, etc.; Rand Rio, which are the same or different, represent hydrogen, etc.; X represents O or CH; and Y represents C(&#x2550;O)); a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof is used as an anxiolytic drug, antidepressant, etc.

A morphinan derivative represented by the following general formula (I): (wherein Rrepresents hydrogen, Calkyl, cycloalkylalkyl where the cycloalkyl moiety has 3 to 6 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms, etc.,

A rectifying section and a DCDC converter which lowers an input DC voltage and then outputs the voltage are disposed between an AC generator and a load When the output voltage Vt of the AC generator is gradually lowered with starting from E the output power P is increased, and is maximum at Vt&equals;V When the output voltage Vt is further lowered, the output power P is reduced. As an operating point at which the same output power P is obtained, there are a point of Vt&equals;V and that of Vt&equals;V The operation of the DCDC converter is controlled so as to operate at the point of Vt&equals;V where the output current I is lower.

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Saitama, Japan

Masaaki Hirose