Kissei Pharmaceutical Co., Ltd.

Masaaki Ban

Makio Kitazawa

Masuo Akahane

Michihiro Kobayashi

Atsushi Tsubaki

Yasushi Nakano

Kazuaki Sato

Ken Kikuchi

Minoru Kubota

Kosuke Okazaki

Toshiaki Yamaguchi

Tetsuji Ozawa

Takashi Yanagi

Ryoichi Yamagishi

Toshikazu Yazaki

Motoyasu Ozawa

The present invention provides novel phenol derivatives represented by the formula: wherein the carbon atom marked with (S) represents a carbon atom in S configuration; Z represents the group represented by the formula: or the formula: wherein the carbon atoms marked with (R) represents a carbon atom in R configuration, and a method to produce a phenol derivative represented by the formula (A): (wherein the carbon atom marked with (R) and (S) have the same meanings as defined above) which comprises using any of those derivatives as an intermediate therefore.

Phenol derivatives and method of use thereof

Indoline compounds represented by the formula: ##STR1## wherein R represents a saturated or unsaturated aliphatic acyl group which may have one or more halogen atoms, a hydroxy group, a lower alkoxy group, a carboxy group, a lower alkoxycarbonyl group, a cycloalkyl group or an aryl group as substituents; a hydroxyalkyl group; an aliphatic acyloxyalkyl group; a lower alkyl group having a lower alkoxy group, a carboxy group, a lower alkoxycarbonyl group, an aryl substituted lower alkoxycarbonyl group, a carbamoyl group, a mono- or dialkyl substituted carbamoyl group or a cyano group as substituents; an aromatic acyl group which may have one or more halogen atoms as substituents; a furoyl group or a pyridylcarbonyl group; R.sup.1 represents a lower alkyl group which may have one or more halogen atoms or an aryl group as substituents; and pharmaceutically acceptable salts thereof, exhibit a selective suppressive action on urethral contractions, and thus are useful as therapeutic agents for the treatment of dysuria with less hypotension including postural hypotension.

1,5,7-trisubstituted indoline compounds and salts thereof

The present invention provides a novel class of naphthylsulfonylalkanoic acid compounds such as a structure corrresponding to the formula: ##STR1## or a pharmaceutically acceptable salt thereof. A present invention naphthylsulfonylalkanoic acid compound is useful for prevention or treatment of irritable bowel syndrome, biliary dyskinesia and acute pancreatitis.

Naphthysulfonylalkanoic acid compounds and pharmaceutical compositions

The present invention provides a novel class of phenylsulfonylalkanoic acid compounds such as a structure corresponding to the formula: ##STR1## or a pharmaceutically acceptable salt thereof. A present invention phenylsulfonylalkanoic acid compound is useful for prevention or treatment of irritable bowel syndrome, biliary dyskinesia and acute pancreatitis.

Phenylsulfonylalkanoic acid compounds and pharmaceuticals thereof

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Matsumoto, Japan

Masaaki Ban