Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai

Microbial Chemistry Research Foundation

Other

Banyu Pharmaceutical Co. Ltd

Kanegafuchi Kagaku Kogyo Kabushiki Kaisha

Bristol-Myers Company

Meiji Seika Kaisha, Ltd.

Meiji Seika Pharma Co., Ltd.

Hokko Chemical Industry Co., Ltd.

501 Azidan Hojin Biseibutsu Kagaku Kenkyu Kai

Zaidin Hojin Biseibutsu Kagaku Kenky Kai

Masa Hamada

Tomio Takeuchi

Hamao Umezawa

Hiroshi Naganawa

Takaaki Aoyagi

Masaaki Ishizuka

Shinichi Kondo

Toshikazu Oki

Tsutomu Sawa

Yasuhiko Muraoka

Taiji Inui

Hironobu Iinuma

Masayuki Igarashi

Yoshiaki Takahashi

Kenji Maeda

Masaji Sezaki

Tomohisa Takita

Kunio Isshiki

Shuichi Gomi

Yoshiro Okami

Akira Takamatsu

Toshiaki Miyake

Haruo Yamamoto

Masaya Imoto

Takeshi Hara

Takeshi Uchida

Yoshikazu Takahashi

Nobuyoshi Shimada

Hajime Morishima

Ikuo Matsumoto

Makoto Tsuda

Keiji Ogawa

Toshiharu Nagatsu

Yoko Ikeda

Tetsuo Shitara

Shuichi Iwadare

Machiko Nagai

Hideo Chimura

Sumio Umezawa

Masatoshi Abe

Hideki Hashizume

Hiroshi Tone

Hiroo Hoshino

Kazuo Umezawa

Tomomi Kosugi

Hiroyuki Kumagai

Hiroshi Imai

Kazuo Kitai

Tetsuo Akiyama

Tomohide Ida

Yoshimitsu Naniwa

Kiyoshi Sato

Yoshinori Sugimoto

Akiko Takeuchi

Kunihito Watanabe

Shigemi Yoshida

Takayuki Aoyama

Takashi Yamashita

Mitsuhiro Ueno

Emiko Muratani

Kiyoto Ishii

Takaaki Nishikiori

Takami Tomiyama

Caprazene is provided which is the compound represented by the following formula (I) wherein Me stands for methyl group, and a 5&#x2033;-N-alkoxycarbonyl or 5&#x2033;-N-aralkyloxycarbonyl derivative thereof, and wherein said compound has theH-NMR andC-NMR data as set forth in Table 15.

Caprazene as a novel compound and derivatives thereof, and caprazol as a novel compound and derivatives thereof

Caprazene and caprazol could be synthesized by hydrolysis of a caprazamycin. There could be synthesized a caprazene-1'&#x2033;-amide derivative of the formula (II) and a caprazene-1&#x2032;&#x2033;-ester derivative of the formula (III) from caprazene. Further, there could be synthesized a caprazol-1&#x2032;&#x2033;-amide derivative of the formula (V) and a caprazol-1&#x2032;&#x2033;-amide-3&#x2032;&#x2033;-ester derivative and a caprazol-3&#x2032;&#x2033;-ester derivative, etc. from caprazol. Furthermore, an imidazolidinone derivative could be synthesized from the ring-opened product of the 1,4-diazepinone ring of caprazol. The novel caprazene derivative, novel caprazol derivative and novel imidazolidinone derivative now synthesized exhibit excellent antibacterial activities against a variety of bacteria, including acid-fast bacteria.

Caprazene as novel compound and derivatives thereof, and caprazol as novel compound and derivatives thereof

By culturingsp. BMK333-48F3 (deposit number of FERM BP-7477), an antibiotic, tripropeptin Z, tripropeptin A, tripropeptin B, tripropeptin C or tripropeptin D represented by the general formula (I): wherein R is 7-methyl-octyl group, 8-methyl-nonyl group, 9-methyl-dodecyl group, 10-methyl-undecyl group or 11-methyl-dodecyl group, is obtained as antibiotics having excellent antibacterial activities against bacteria and having a novel molecular structure. These tripropeptins each have an excellent antibacterial activity against various bacteria and drug-resistant strains thereof, such as methicillin-resistant strains and vancomycin-resistant strains.

Antibiotics, tripropeptins and process for producing the same

Antibiotic caprazamycins and process for producing the same

Benzofurylpyrone derivatives

20,23-disubstituted mycaminosyltylonolide derivatives and use of the same in the field of the prophylaxis and treatment of pasteurellosis are disclosed. The di-substituents are peperidino optionally substituted with one or two methyl groups. The derivatives have selective antibacterial activity against Pasteurella.

Macrolide antibiotics and treatment and prophylaxis of pasteurellosis using the same

As novel substances having an activity of inducing an apoptosis even on the apoptosis-resistant cancer cells, there are obtained polyoxypeptin and deoxypolyoxypeptin represented by the following general formula (I)

Physiologically active polyoxypeptin and deoxypolyoxypeptin and anticancer drugs containing the same

This invention provides a physiologically active substance having a strong dipeptidyl peptidase IV inhibitory activity. The physiologically active substance sulphostin is obtained by culturing a microorganism belonging to the genus Streptomyces and having an ability to produce the physiologically active substance sulphostin, producing and accumulating this substance in the cultures, and harvesting it from the cultures.

Physiologically active substance sulphostin, process for producing the same, and use thereof

Pharmaceutical composition for inhibiting the infection with AIDS virus

Antibiotics having immunosuppressive activity, delaminomycins and

A novel, biologically active substance, poststatin, has been isolated from a culture medium of microorganism belonging to Streptomyces. The novel substance is a peptide compound having a novel structure, wherein the peptide chains have ketone radicals. Thus substance has a high endopeptidase inhibition activity. It is possible to chemically synthesize poststatin related compound having ketone radicals in the peptide chains. These compounds also have an endopeptidase inhibition activity.

Poststatin and related compounds or salts thereof

Benanomicin A and Benanomicin B are fermentatively produced by the cultivation of a new microorganism Actinomadura spadix, designated as MH193-16F4 strain.

Process for the simultaneous production of benanomicins A and B

Polyether antibiotic MI215-NF3 substance, production process thereof,

Benastatins A and B which are novel and physiologically active substances having the formula ##STR1## wherein R represents --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--, exhibit a potent immunomodifier activity, a glutathione transferase inhibition activity and an anti-microorganism activity and are therefore extremely useful for various drugs.

Physiologically active substances, benastatins A and B, and production

Growing community of inventors

Tokyo, Japan

Masa Hamada