Universidade De Santiago De Compostela

María José Alonso Fernández

Marcos García Fuentes

Felipe Andrés Oyarzún Ampuero

José Vicente González Aramundiz

Gustavo Rivera Rodriguez

Giovanna Lollo

Noemi Csaba

Dolores Torres Lopez

Teresa Gonzalo Lázaro

The present invention relates to the design and development of nanocapsule systems for the administration of active substances, wherein the nanocapsules of the system have a mean diameter less than 1 &#x3bc;m and are characterized by comprising (a) a protamine shell, (b) an oily core, and one or more surfactants characterized by having a hydrophilic-lipophilic ratio greater than 8, provided that said surfactant is not a phospholipid.

Nanocapsules of protamine

The invention relates to a system for administering active ingredients, including nanocapsules comprising an oil, a cationic surfactant and a polymer selected from the group consisting of polyglutamic acid (PGA), polyglutamic-polyethyleneglycol acid (PGA-PEG), hyaluronic acid (HA) and polyasparagine (PAsn) or a combination of same and, optionally, an active ingredient, with the condition that when the polymer includes polyglutamic acid or polyglutamic-polyethyleneglycol acid (PGA-PEG) the active ingredient is not a didemnin or a tamandarin. The invention also relates to methods for obtaining said nanocapsule system, the pharmaceutical compositions thereof and the use of same in medicine.

Nanocapsules with a polymer shell

Growing community of inventors

Santiago de Compostela, Spain

María José Alonso Fernández