Fundacíon Tecnalia Research & Innovation

María Del Mar Díaz De Guereñu Zabarte

José Ramón Ochoa Gómez

Inés Rincón Arroyo

Soraya Prieto Fernández

Tomás Roncal Martínez

Susana Pérez Gil

Susana Caballero Román

The present invention relates to a method for continuous production of 2,3-butanediol by hydrogenation of 3-hydroxybutanone with hydrogen in the presence of a heterogeneous hydrogenation catalyst filled in one or more fixed-bed flow tubular reactor systems comprising one or more tubes with an inner diameter from 1 mm to 6 mm.

Method for continuous production of 2,3-butanediol

The present invention provides a modified strain of the bacteriumobtainable by a method that comprises a step of fusion of two protoplasts from twoparental strains which, compared to the wild type strain offrom which they derive, show: (a) an increased ability to produce acetoin and/or 2,3-butanediol (2,3-BDO), and (b) a decreased ability to produce lactic acid, when cultured under aerobic conditions, and wherein the modified strain ofhas an increased ability to produce 2,3-BDO of at least 20 times the amount produced by the wild type strain, an increased ability to produce acetoin of at least 20 times the amount produced by the wild type strain and a decreased ability to produce lactic acid of at least 10 times the amount produced by the wild type strain, when cultured under aerobic conditions. Also provided are methods to produce acetoin and 2,3-BDO.

Bacterial strain producing 2,3-butanediol and other metabolites

Growing community of inventors

Miñano, Spain

María Del Mar Díaz De Guereñu Zabarte