Lipha, Lyonnaise Industrielle Pharmaceutique

Maryse Belleville

Michel Bayssat

Jean-Claude Lechevin

Marcel Grand

Francoise Merle

Long-acting forms of theophylline for use in treating asthma comprise theophylline associated with a compound of the substituted cinnamamide type of the general formula ##STR1## wherein R is hydrogen, a hologen or an acetyl radical; R.sub.1 is hydrogen or the methyl radical; R.sub.2 is ##STR2## wherein R.sub.3 is hydrogen or the methyl radical; or R.sub.1 and R.sub.2 together with the adjacent nitrogen tom form the 2,2-dimethyl-3-oxazolidinyl group.

Long-acting theophylline in medicinal form

An orally administrable pharmaceutical composition comprises a dosage of the acid oralate of naftidrofuryl having a prolonged release coating which is a film formed from hydroxypropyl methyl cellulose and ethyl cellulose, the content of ethyl cellulose being between 30 and 50% and containing 8 to 15% of propylene glycol relative to the total of the cellulose derivatives. The composition, having prolonged therapeutic activity is capable of being used in the treatment of arterial diseases in limbs, circulatory disorders in the hands and feet, cerebral vascular disorders and diffuse circulatory insufficiency with elderly people.

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Lyon, France

Maryse Belleville