Immunex Corporation

Other

Marylou G Gibson

Richard Jeffrey Armitage

William Christian Fanslow, Iii

Melanie K Spriggs

Subhashini Srinivasan

Arvia Eleanor Morris

Jeffrey T McGrew

There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human and murine CD40-L polypeptides that bind to the extracellular binding region of a CD40 receptor.

DNA encoding CD40 ligand, a cytokine that binds CD40

There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human and murine CD40-L polypeptides that bind to the extracellular binding region of a CD40 receptor. Also disclosed are methods of simulating hybridoma cells to increase monoclonal antibody production by administering a CD40 ligand polypeptide that stimulates B cell proliferation.

Use of CD40 ligand, a cytokine that binds CD40, to stimulate hybridoma cells

Method of augmenting a vaccine response by administering CD40 ligand

There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human and murine CD40-L polypeptides that bind to the extracellular binding region of a CD40 receptor. Also disclosed are methods of inhibiting undesirable immune responses, preventing T cell interaction with B cells by blocking CD40L binding to CD40 sites on B cells and other target cells.

Methods of inhibiting CD40L binding to CD40 with soluble monomeric CD40L

Recombinant soluble CD40 ligand polypeptide and pharmaceutical

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Carlsbad, CA, United States of America

Marylou G Gibson