Becton Dickinson and Company Limited

C. R. Bard, Inc.

Marybeth Sharkey

Oleg Guryev

Majid Mehrpouyan

Shumeye Mamo

Aaron J Middlebrook

Jeffrey Chun Wang

Michael Adam Randall

Michael A Randall

Hiep Do

Tatyana Chernenko

Jeffrey Wang

Elena Afonina

Emily Goel

Cyal Lecy

Multiplex polymeric dye devices are provided. Aspects of the devices include a solid support, and first and second dried polymeric dye compositions distinctly positioned relative to a surface of the solid support. Aspects of the invention further include methods of making and using the devices, e.g., in analyte detection applications, as well as kits containing the devices.

Multiplex polymeric dye devices and methods for using the same

Drug-loaded microbead compositions include microbeads of a biodegradable material and vesicular agents located within or associated with the biodegradable material of the microbeads. The vesicular agents include a lipid bilayer and comprise liposomes or ethosomes. The drug-loaded microbeads include a first therapeutic agent associated with the vesicular agents, and a second therapeutic agent different from the first therapeutic agent. The vesicular agents include a lipid bilayer surrounding a vesicular core. The second therapeutic agent is contained within the microbeads or associated with the microbeads through ionic or non-covalent interaction and may or may not be associated with the vesicular agents. Drug-loaded biodegradable microbead compositions include microbeads of biodegradable material and a therapeutic agent.

Drug-loaded biodegradable microbead compositions including drug-containing vesicular agents

Methods and devices for producing a population of liposomes are provided. Aspects of the methods include applying a centrifugal force to a suspension of liposomes in a manner sufficient to pass the liposomes through a porous membrane to produce a population of liposomes. Aspects of the invention further include devices, systems and kits useful for performing the methods.

Liposomes and methods of production thereof

Method for liposome preparation by centrifugation

Inverting device for liposome preparation by centrifugation

Methods and devices for liposome preparation by centrifugation

Described herein are aqueous soluble polymersomes that encapsulate one or more hydrophobic fluorescent polymers and methods of their preparation and use.

Polymersome encapsulation of hydrophobic fluorescent polymers

Chromophore compositions and methods of making and using the same are provided. Aspects of the chromophore compositions include a chromophore component having a chromophore, such as a fluorescent dye moiety, stably associated with a prosthetic group binding cavity of a metalloprotein. Also provided are methods of making, methods of use, systems and kits related to the subject fluorescent compositions.

Chromophore compositions and methods of making and using the same

The present invention provides labeling and capture reagents that comprise phosphorothioate oligonucleotides (PS-ODN). The PS-ODN bind to all white blood cells (leukocytes) in an indiscriminative fashion and enable the labeling, capture, or concentration of leukocytes in a manner that preserves the antigenic integrity of the cells. Methods for the use of phosphorothioate oligonucleotides are provided.

Phosphorothioate oligonucleotide-labeling of white blood cells

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San Jose, CA, United States of America

Marybeth Sharkey