Cytosorbents Corporation

Pharmaseq, Inc.

Maryann Gruda

Thomas D Golobish

Tamaz Guliashvili

Vincent J Capponi

Phillip Chan

Wei-Tai Young

Andrew Scheirer

Pamela O'Sullivan

Vi Dan

Wlodek Mandecki

Ziye Jay Qian

Ziye “Jay” Qian

Ziye (Jay) Qian

Gary H Reitnauer

Josh Vichare

David James

Timothy Kovacs

Karl-Gustav Ruggeberg

Sarah Patterson

Hanan Davidowitz

Edward Kuspiel

Joseph Nolfo

The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.

Multi-functional hemocompatible porous bead sorbent for removing protein based toxins and potassium from biological fluids

The invention concerns polymeric media based on modified natural polysaccharides for removing one or both of Anti-A Antibodies and Anti-B Antibodies from human blood or plasma, the media comprising one or both of (i) a polymeric solid support with a blood group A Antigen ligand attached to the solid support at a ligand loading between 1-5 mg/mL of solid support, and wherein the media is stable under physiological pH conditions, and (ii) a polymeric solid support with a blood group B Antigen ligand attached to the solid support at a ligand loading between 1-5 mg/mL of solid support, and wherein the media is stable under physiological pH conditions.

Crosslinked polysaccharide based absorbents for removal of anti-A and/or anti-B antibodies from human plasma and whole blood

The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.

Use of a hemocompatible porous polymer bead sorbent for removal of endotoxemia-inducing molecules

Multi-functional hemocompatible porous polymer bead sorbent for removing protein based toxins and potassium from biological fluids

This invention discloses methods for reducing physiologic molecules in abnormal levels and/or exogenous toxins in blood from blood by way of an extracorporeal circuit comprising a hollow-fiber filter module and polymer sorbent in combination.

Methods for removal of toxins from blood using an extracorporeal circuit comprised of a hollow-fiber filter module and polymer sorbent in combination

Provided among other things is a tagging system for identifying closely proximate stacked items (e.g., thin and flat closely spaced items) each of which is tagged with an electronic radiation emitting chip with a built-in antenna incorporated therein. The tagging system comprises: (1) the tagged, closely spaced items, wherein the electronic radiation emitting chips are affixed on, and within the width of, thin side edges of the items; and (2) an ID reader capable of reading the IDs (identifiers) stored electronically on the chips, wherein the electronic radiation emitting chips are sufficiently aligned on the items such that the chips can be serially read with the ID reader.

Electronic chip-based tagging system for identifying closely proximate thin and flat items

Provided herein, among other things, is an assembly consisting of a tissue cassette or slide and an affixed transponder.

Tagging of tissue carriers with light-activated microtransponders

Provided are methods and apparatus including an injector system adapted for injecting a microchip comprising: an inserter comprising a rod or tube having a proximal and distal end and having a point at the distal end that defines a skin-piercing side of the inserter; a means for engaging the microchip near the distal end of the inserter, but removed in the proximal direction from the distal tip of the inserter, which means prevents rotation of an engaged microchip in two or three axes of rotation; and means for releasing the microchip from the inserter once the inserter has been inserted into a perforatable substrate.

Apparatus and method to deliver a microchip

Growing community of inventors

Yardley, PA, United States of America

Maryann Gruda