Human Biomolecular Research Institute

Mary T MacDonald

John R Cashman

The present disclosure provides organophosphorous (OP) compounds of Formula (I), Formula (II) and Formula (III):OP-Peptide-Linker-CP&#x2003;&#x2003;(I),OP-Peptide-Linker&#x2003;&#x2003;(II); and  including that structure corresponding to a reactive organophosphorous reagent, nerve agent or pesticide, or a pesticide P&#x2550;S to P&#x2550;O metabolite; P is the Sor Rstereoisomer; X is oxygen, sulfur, selenium or imino; R and R' are as described; Peptide is a sequence of amino acids containing a serine, threonine or tyrosine to which the OP is attached, wherein the total number of amino acids is between 7 and 41; Linker is an amino acid or is derived from another bifunctional reagent capable of covalently attaching an OP-peptide to a CP; and CP is a carrier protein used to display haptens for antibody generation. The disclosure also provides methods for generating monoclonal or polyclonal antibodies specific for an OP-Peptide of a compound of Formula (I) or Formula (II) that can be used to diagnose the presence, identity, and quantity of OP adducts.

Growing community of inventors

San Diego, CA, United States of America

Mary T MacDonald