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Protein Technologies International, Inc.

Mary Susan Anthony

Yuanlong Pan

Doyle H Waggle

Thomas B Clarkson

Michael R Adams

Morris Notelivitz

Thomas Boston Clarkson, Jr

A composition for improving memory and concentration in mammals with disorders associated with memory impairment. The composition comprises a combination of at least one phytoestrogen and at least one acetylcholinesterase inhibitor such as Huperzine A, or any derivative, analog, metabolite or combination thereof. The composition may further include at least one mammalian estrogen. The method of the invention comprises the co-administration of at least one phytoestrogen and at least one acetylcholinesterase inhibitor in a therapeutically effective amount. Additionally, a mammalian estrogen may be co-administered.

COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING NEURODEGENERATION AND COGNITIVE DECLINE AND DYSFUNCTION ASSOCIATED WITH ALZHEIMER'S DISEASE, AGING, OTHER DEMENTIA RELATED DISORDERS AND ESTROGEN DEFICIENCY RELATED CONDITIONS

Methods for inhibiting the development and relieving the symptoms of Alzheimer's disease and related dementias are provided. A phytoestrogenic isoflavone compound is administered to a human predisposed to developing Alzheimer's disease or a related dementia, or having Alzheimer's disease or a related dementia, in an amount effective to inhibit the development or relieve the symptoms of the disease. The phytoestrogenic isoflavone compound is selected from at least one of genistein, genistin, 6'-OMal genistin, 6'-OAc genistin, daidzein, daidzin, 6'-OMal daidzin, 6'-OAc daidzin, glycitein, glycitin, 6'-OMal glycitin, or mixtures thereof. The phytoestrogenic isoflavone compound is effective to up-regulate choline acetyltransferase mRNA and nerve growth factor mRNA.

Method for inhibiting the development of Alzheimer's disease and related

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Clemmons, NC, United States of America

Mary Susan Anthony