Auburn University

Other

The University of Arizona

Mary Smith Cupp

Eddie Wayne Cupp

Dunhua Zhang

Jose M C Ribeiro

Latora W Todd Jackson

Christine Navarre

Eugene Blair

Steven F Swaim

Jose M Ribeiro

Thrombostasin is an anti-clotting protein found in saliva of. Disclosed herein are studies testing blood uptake of horn flies feeding on cattle which confirm the association of ts genotype with blood uptake of horn flies. Blood uptake volumes of homozygous ts10 horn flies were lower than those of other ts genotypes when fed on control cattle. Cattle vaccinated with recombinant protein isoforms rTS9 or rTB8 resisted horn fly feeding by yielding lower blood volumes compared to flies feeding on control cattle. The impact of vaccination varied by ts genotype of flies. Cattle vaccinated with isoforms rTS9 resisted flies of ts2, ts9, and tb8 genotype. Vaccination with isoforms rTB8 produced resistance to ts8, ts9 and tb8 genotype flies. Horn flies of genotype ts10 were not affected with either TS isoforms and fed well on rTS9 and rTB9 vaccinated as on control-vaccinated cattle.

Combination of protein forms for hornfly vaccination

The invention is drawn to anti-thrombin proteins from the salivary glands of the species,. Methods for recombinant production of the protein as well as biomedical uses are provided.

Antithrombin protein and DNA sequences from black fly

Compositions and methods for preventing hematophagous infestation of cattle are provided, directed at isolated proteins that disrupt platelet aggregation. Also provided are nucleotide sequences encoding the proteins. The exemplary haematollogen protein was isolated from the salivary glands of. The compositions are useful as veterinary vaccines in prevention of blood-feeding in cattle by the infesting horn fly and are also useful in treatment of thrombosis.

Protein from horn fly saliva that disrupts hemostasis

Compositions and methods for preventing hematophagous infestation of cattle are provided, directed at isolated proteins with antithrombin activity and nucleotide sequences encoding the proteins. The protein named thrombostasin is isolated from the salivary glands of. The compositions are useful as veterinary vaccines in prevention of blood-feeding in cattle by the infesting horn fly. The proteins of the invention are also useful in treatment of thrombosis.

Antithrombin nucleotides and proteins from horn fly

The invention is drawn to anti-thrombin proteins from the salivary glands of the species, . Methods for recombinant production of the protein as well as biomedical uses are provided.

The invention is drawn to vasodilative proteins from the salivary glands of the species, Simulium. The protein additionally has immunomodulating activities. Methods for recombinant production of the protein as well as biomedical uses are provided.

Methods of use of recombinant vasoactive protein from salivary gland of the black fly

Recombinant vasoactive protein from salivary gland of the black fly

The invention is drawn to anti-thrombin proteins from the salivary glands of the species, Simulium. Methods for recombinant production of the protein as well as biomedical uses are provided.

Compositions and methods for preventing hematophagous infestation of cattle are provided, directed at isolated proteins with antithrombin activity and nucleotide sequences encoding the proteins. The protein named thrombostasin is isolated from the salivary glands of The compositions are useful as veterinary vaccines in prevention of blood-feeding in cattle by the infesting horn fly. The proteins of the invention are also useful in treatment of thrombosis.

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Auburn, AL, United States of America

Mary Smith Cupp