Microbia, Inc.

Cytokinetics, Inc.

Mary Maxon

Kevin T Madden

Amir Sherman

Thea Norman

John C Royer

Brian Cali

Douglas A Holtzman

Peter Hecht

Eric Summers

Todd Milne

Sofie Salama

Robert Busby

Doug Holtzman

Jeff Silva

David M Roof

Methods for improving the production of a secondary metabolite by a fungus by increasing the yield or productivity of the secondary metabolite produced by the fungus are described. The methods include increasing the expression of LYS14, for example, by transforming a cell with a nucleic acid molecule encoding LYS14.

Modulation of secondary metabolite production by zinc binuclear cluster proteins

The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for improving secondary metabolite production in a fungus, comprising modulating the expression of a gene involved in regulation of secondary metabolite production.

Methods for improving secondary metabolite production in fungi

Provided are methods of identifying potential antifungal agents, and particularly those having antimitotic activity. Fungal cells having double mutations which alter microtubule stability and inhibit cell proliferation are used in the methods. Test compounds are screened to identify those which are able to promote cell proliferation o the mutant fungal cells and counteract the stabilizing effect of the double mutations on the microtubules. High-throughput methods of selecting for the novel antifungal agents are also provided.

Double motor mutant assay for antifungal agents

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San Francisco, CA, United States of America

Mary Maxon