Rutgers, the State University of New Jersey

Mary Maral Mouradian

Michael Voronkov

Steven P Braithwaite

Eunsung Junn

Methods of treating patients with dyskinesias, by administering a therapeutically effective amount of a dual-action mu-opioid receptor antagonist/kappa-opioid receptor agonist or prodrug thereof to a subject in need thereof, sufficient to mitigate the dyskinesia. Alternatively, a combination of both a mu-opioid receptor antagonist or prodrug thereof, and a kappa-opioid receptor agonist or prodrug thereof can be administered, either together or separately.

Method of treating dyskinesia

Therapies and assays to screen for small molecules that can have therapeutic use in the control of neurodegenerative diseases such as Parkinson's and other alpha-synucleinopathies.

Growing community of inventors

Princeton, NJ, United States of America

Mary Maral Mouradian