Amylin Pharmaceuticals, Inc.

Astrazeneca Pharmaceuticals LP

Mary L Houchin

Scott H Coleman

Hong Qi

Robert N Jennings

Robin Lee

Greg Oehrtman

Robin H Lee

The disclosure provides one-component, injectable, sustained release formulations which comprise microspheres containing active pharmaceutical ingredients (e.g., exenatide), wherein the microspheres are suspended in a non-aqueous carrier. The non-aqueous carrier can be an oil, a fractionated oil, triglycerides, diglycerides, monoglycerides, propylene glycol fatty acid diesters, and the like. The formulations offer distinct advantages of long shelf life for the stability and potency of the formulation and sustained release of active pharmaceutical ingredients to reduce the frequency of medication dosing and to increase patient compliance.

Sustained release formulations using non-aqueous carriers

Growing community of inventors

Rockville, MD, United States of America

Mary L Houchin