US Government as Represented by the Secretary of the Army

United States Army Medical Research Institute of Infectious Diseases Department of the Army

U.S. Medical Research Institute of Infectious Diseases

Mary Katherine Hart

Julie A Wilson

Gene Garrard Olinger, Jr

Michael Adam Bailey

Maryam Azarion

Julie Ann Wilson

Peter Pushko

Jonathan F Smith

Using CTL epitopes to theGP, NP, VP24, VP30, VP35 and VP40 virion proteins, a method and composition for use in inducing an immune response which is protective against infection withvirus is described.

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In this application is described a method for overcoming alphavirus vaccine interference in alphavirus-immune subjects by administration of a second alphavirus vaccine which is altered such that it is not accessible to interfering antibodies. Examples of such alterations are described as well as evidence showing that alphavirus interference likely results from the binding of interfering antibodies to viral proteins expressed on infected cells thereby causing lysis of infected cells.

Overcoming interference in alphavirus immune individuals

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Frederick, MD, United States of America

Mary Katherine Hart