The Dupont Merck Pharmaceutical Company

E.i. Dupont De Nemours and Company

Mary K VanAtten

Richard Eric Olson

Mimi Lifen Quan

Joseph B Santella

John J Duncia

Carol L Ensinger

Novel substituted imidazoles of Formula (I), which are useful as angiotensin II antagonists, are disclosed: ##STR1##

Imidazole 5-position substituted angiotensin II antagonists

Novel substituted imidazoles of Formula (III), which are useful as angiotensin-II antagonists, are disclosed: ##STR1## These compounds, exemplified by the compound 1-((2'-((i-Amyloxycarbonylamino)sulfonyl)-3-fluoro-(1,1'-biphenyl)-4-yl)me thyl)-5-[2-(N-butyryl-N-pyridin-3-ylamino) ethylcarbonyl]-4-ethyl-2-propyl-1H-imidazole, are useful as antihypertensive agents.

Provided are 1,2,3,4-tetrahydroisoquinolines, methods for preparing them, pharmaceutical compositions containing them, and methods of using them to treat disorders of mammals mediated by AT.sub.2 receptors in the central nervous system.

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Wilmington, DE, United States of America

Mary K VanAtten