Krystal Biotech, Inc.

Mary Jane Duermeyer

Suma Krishnan

Trevor Parry

Dana Michelle Previte

The present disclosure provides recombinant nucleic acids comprising one or more polynucleotides encoding an immunomodulatory polypeptide (e.g., a pro-inflammatory cytokine such as a human IL-2 or IL-12 polypeptide); viruses comprising the recombinant nucleic acids; compositions and formulations comprising the recombinant nucleic acids and/or viruses; methods of their use (e.g., for the treatment of cancer, such as lung cancer); and articles of manufacture or kits thereof.

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Glenshaw, PA, United States of America

Mary Jane Duermeyer