University of Washington

Genevant Sciences Gmbh

Phaserx, Inc.

Marina Biotech, Inc.

Mary Gallagher Prieve

Charbel Diab

Pierrot Harvie

Michael E Houston, Jr

Allan Sachs Hoffman

Patrick S Stayton

Anna S Gall

Paul Hickok Johnson

Robert W Overell

Sean D Monahan

Priyadarsi De

Steven C Quay

Craig L Duvall

Anthony Convertine

Danielle Benoit

Roger C Adami

Kathy L Fosnaugh

Shaguna Seth

Anna Galperin

Michael S DeClue

Amber E E Paschal

Renata Fam

Debashish Roy

Amber E Paschal

Maher Qabar

Russell N Johnson

Michael E Houston

Jean-Rene E Ella-Menye

Amber Ee Paschal

Anthony J Convertine

Paul Johnson

Paul H Johnson

Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the block copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the block copolymer is endosomolytic and capable of delivering an oligonucleotide (e.g., an mRNA) to a cell. Compositions comprising a block copolymer and an oligonucleotide (e.g., an mRNA) are also disclosed.

Block copolymers

Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instauces, micellic assemblies provided herein are pH sensitive particles.

Micellic assemblies

Disclosed are branched PEG molecules, including branched PEG-lipids and branched-PEG proteins, as well as related compositions and methods for making branched PEG molecules. Also disclosed are related compositions, systems, and methods for in vivo delivery of therapeutic and diagnostic agents.

Branched peg molecules and related compositions and methods

Disclosed are methods for delivering a therapeutic or diagnostic agent to the cytosol of a cell in a subject. The disclosed methods generally include administering to the subject an effective amount of a lipid nanoparticle comprising the therapeutic or diagnostic agent and an effective amount of a membrane-destabilizing polymer. Also disclosed are related compositions and delivery systems.

Methods, compositions, and systems for delivering therapeutic and diagnostic agents into cells

Nucleic acid constructs and methods of using the same

This disclosure provides a range of tyrosine amino acid lipid compounds and compositions useful for drug delivery, therapeutics, and the diagnosis and treatment of diseases and conditions. The amino acid lipid compounds and compositions can be used for delivery of various agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects.

Tyrosine-based lipids for delivery of therapeutics

Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instances, micellic assemblies provided herein are pH sensitive particles.

Provided herein are multiblock copolymers, as well as micelles and therapeutic compositions thereof.

Multiblock copolymers

This disclosure provides a range of amino acid lipid compounds and compositions useful for drug delivery, therapeutics, and the diagnosis and treatment of diseases and conditions. The amino acid lipid compounds and compositions can be used for delivery of various agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects.

Arginine-based lipids for delivery of therapeutics

Compositions comprising a heterogeneous polymeric micelle and an agent (e.g., a polynucleotide) associated with the micelle are disclosed, together with methods for intracellular delivery of such agent.

Heterogeneous polymeric micelles for intracellular delivery

Provided herein are polymeric carriers suitable for the delivery of polynucleotides (e.g. oligonucleotides) and/or other therapeutic agents into a living cell.

Polymeric carrier

Growing community of inventors

Lake Forest Park, WA, United States of America

Mary Gallagher Prieve