Wisconsin Alumni Research Foundation

Mary E Phelps

Hector Floyd Deluca

Heinrich K Schnoes

Seok H Lee

Rafal R Sicinski

Kato L Perlman

Andrzej Kutner

Connie M Smith

Zu Y Cai

Calcitriol derivatives and their uses

The invention relates to a method for preparing vitamin D-related compounds and to certain intermediate compounds in such process. The intermediate compounds are characterized by an aldehyde or ester in the C-22 position in the side chain. The presence of such groups permit facile side chain additions for the preparation of vitamin D derivatives.

Vitamin D related compounds and processes for their preparation

The invention relates to a process for preparing 1-hydroxyvitamin D compounds by acid-catalyzed solvolysis of the corresponding 1-hydroxy-3,5-cyclovitamin D compound in an organic solvent medium whereby the free, non-acylated, 5,6-cis and 5,6-trans-1-hydroxylated vitamin D compounds are obtained in admixture.

Method for preparing 1-hydroxyvitamin D compounds

The invention relates to a process for separating 1.alpha.-hydroxyvitamin D compounds from their corresponding 1.alpha.-hydroxy-5,6-trans isomers in a mixture thereof by treating the mixture with a dienophile and then separating the resulting dienophil-adduct of the 1.alpha.-hydroxy-5,6-trans vitamin D isomer from the unreacted 1.alpha.-hydroxyvitamin D compound.

Method for preparing 1.alpha.-hydroxyvitamin D compounds

Growing community of inventors

Stoughton, WI, United States of America

Mary E Phelps