New York University

The State University of New York

London Health Sciences Centre Research Inc.

Mary Cowman

Philip A Band

Hans-Georg Wisniewski

Miriam Rafailovich

Eva Ann Turley

Leonard Luyt

Divya Bhatnagar

Han Yuan

Cornelia Toelg

Ripal Amin

Thorsten Kirsch

Eric J Strauss

The present invention provides a facile method for separation (fractionation) of HA in a sample over a broad M range, including low M HA, by ion exchange (IEX) chromatography. The present invention also provides an assay method for quantifying in a sample the presence of low M HA in total HA isolated from a biological source. The method involves HA fractionation according to M by use of IEX separation, followed by HA-specific assay of HA size range fractions.

Method for separating hyaluronan and quantifying its molecular mass distribution in biological samples

Provided are methods and compositions for cartilage repair. The method involves performing a surgical procedure at the site of a cartilage defect and administering a composition comprising a receptor for hyaluronan mediated motility (RHAMM)-mimetic peptide, and a high molecular weight hyaluronan.

Compositions and methods for cartilage defect repair using a RHAMM-mimetic peptide

The present invention provides a biocompatible material in the form of a water insoluble cross-linked gel, which contains a stable complex of TNF-stimulated gene 6 protein (TSG-6) and hyaluronan.

Biocompatible materials containing stable complexes of TSG-6 and hyaluronan and method of using same

Hydrogels formed from hyaluronic acid, a nanoclay and gelatin-type A. The hyaluronic acid is preferably dissolved in a cell culture medium containing amino acids, salts, glucose, vitamins and an antibiotic to form a hyaluronic acid solution. The gelatin-type A has a weight/volume of from about 0.02% to 0.08%. The nanoclay is exfoliated in deionized water and preferably includes SiO, MgO, NaO and LiO.

Nanocomposite hyaluronic acid-clay based hydrogels

The present invention provides a biocompatible material in the form of a solid, a water insoluble cross-linked gel or a liposome, which contains a stable complexes of TNF-stimulated gene protein (TSG-6) and hyaluronan.

Biocompatible materials containing stable complexes method of TSG-6 and hyaluronan and method of using same

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Mohegan Lake, NY, United States of America

Mary Cowman