Other

The University of Sydney

Polychip Pharmaceuticals Pty Ltd.

Mary Chebib

Graham A R Johnston

Peter M Burden

Jane Hanrahan

Kenneth Noel Mewett

The invention provides compounds of the formula II:wherein R represents propyl, butyl, pentyl, neo-pentyl or cyclohexyl, and salts thereof. These compounds are selective GABAreceptor antagonists. The invention also provides a method of enhancing the cognitive activity of an animal and a method of stimulating memory capacity in an animal, comprising administering to the animal an effective amount of a compound of formula II or a pharmaceutically acceptable salt thereof.

Neurologically-active compounds

The invention provides methods for enhancing cognitive activity and stimulating memory capacity, comprising the step of administering an effective amount of a compound with GABA receptor antagonist activity to an animal in need of such treatment. Preferably the compound has selective GABA receptor antagonist activity, and more preferably comprises a phosphinic acid group. The invention also provides novel compounds and compositions. The methods of the invention are useful in the treatment of dementias and conditions involving cognitive deficit, or memory impairment.

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Leichhardt, Australia

Mary Chebib