Pfizer Corporation

Integrated Chemistry Design, Inc.

Pfizer Products Inc.

Mary Catherine Johnson

Robert Steven Kania

Mason Alan Pairish

Hengmiao Cheng

Mitchell David Nambu

Phuong Thi Quy Le

Jacqui Elizabeth Hoffman

Michael Bruno Plewe

Dilip Ramakant Bhumralkar

Klaus Ruprecht Dress

Khanh Tuan Tran

Jingrong Jean Cui

Indrawan James McAlpine

Susan Elizabeth Kephart

John David Clark

Atsuo Kuki

Cynthia Louise Palmer

Yufeng Hong

Haitao Li

Judith Gail Deal

Junhu Zhang

Chuangxing Guo

Lei Jia

Jayashree Tikhe

Maria Angelica Linton

Hong Shen

Michelle Bich Tran-Dube

Liming Dong

Anle Yang

Danlin Gu

Michelle Bich Tran-Dubé

Junhun Zhang

Dilip Bhumralkar

Phuong Thi Le

Jacqui Elizabet Hoffman

Jayashree Girish Tikhe

A device comprising a display, a user interface configured to receive gesture input, and a processor is provided. The device is configured to electronically detect, with the user interface, at least one gesture input from the user in an approximately circular motion that traces a substantially closed curve without corners about a point on the user interface. The device is configured to display, on a portion of the display, a polygonal shaped chemical structure symbol representing a polygonal ring of carbon atoms in response to the detecting, the polygonal ring having a set number of vertices representing a set number of carbon atoms. A non-transient computer readable medium having instructions stored thereon that cause a device comprising a display, a user interface configured to receive gesture input, and a processor to perform a method is also provided.

Systems and methods of editing a polygonal-shaped chemical structure having a set number of vertices

Gestures for creating chemical structure symbols representing rings of carbon atoms on a touch screen device include circular motions that cause a touch screen enabled device to display symbols representing chemical structures or related information in response to the gestures.

Systems and methods of editing a chemical structure on a touch-screen

The present invention is directed to novel 4-methylpyridopyrimidinone compounds of Formula (I), and to salts thereof, their synthesis, and their use as inhibitors of phosphoinositide 3-kinase alpha (PI3-K&#x3b1;).

4-methylpyridopyrimidinone compounds

Carbonylamino Pyrrolopyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4. 

Carbonylamino pyrrolopyrazoles, potent kinase inhibitors

The present invention is directed to compounds of Formula (I), and to pharmaceutically acceptable salts thereof, their synthesis, and their use as Raf inhibitors.

Pyrazole compounds as RAF inhibitors

The invention relates to compounds of the formula I or a pharmaceutically acceptable salt thereof, wherein R, R, Rand Rare as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.

Triazolopyrazine derivatives

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San Diego, CA, United States of America

Mary Catherine Johnson