Abbott Cardiovascular Systems, Inc.

Symyx Technologies, Inc.

Mary Beth Kossuth

James Oberhauser

Manish Gada

Lothar W Kleiner

Thierry Glauser

Vincent J Gueriguian

Joel Harrington

Bethany Steichen

Stephen D Pacetti

Syed F Hossainy

Paul Mansky

Damian A Hajduk

Fuh-Wei Tang

Xiao Ma

Richard Rapoza

Annie Liu

Jana Buccola

A method of accelerated aging of bioresorbable polymer scaffolds including exposing the scaffold to water is disclosed. The scaffold is exposed to water at a controlled temperature for a selected aging time. The functional outputs, such as radial strength, expandability, and % recoil obtained from aged scaffolds predict those of real-time aging of the scaffold. The accelerated aging factor, which is the required shelf life divided by the aging time, is significantly higher for poly(L-lactide) scaffolds tested than thermal aging.

Accelerated aging for polymeric scaffolds

Bioresorbable polymer vascular scaffolds made of combinations of polylactide and polycaprolactone having a high molecular weight polymer, thin struts in a selected range and sufficient radial strength to support a vessel upon deployment. The scaffolds have degradation behavior of molecular weight, radial strength, and mass that are conducive to healing of a vessel including providing patency to a vessel, reduction of radial strength, breaking up, and resorbing to allow return of the vessel to a natural state.

High molecular weight polylactide and polycaprolactone copolymer and blends for bioresorbable vascular scaffolds

An endoprosthesis, a method for imaging an endoprosthesis, a method of making an endoprosthesis involve a polymeric substrate that has been modified to have voids embedded within the substrate. The voids are sized to scatter optical radiation from within the substrate so that an optical coherence tomography (OCT) image can be obtained in which an interior region of the substrate can be easily differentiated from empty space and other structures that surround the endoprosthesis. The voids allow for OCT visualization of the polymeric substrate which may be difficult to visualize by other methods such as fluoroscopy.

High visibility endoprosthesis and method

Methods to expand polymer tubing with desirable or optimum morphology and mechanical properties for stem manufacture and fabrication of a stent therefrom are disclosed.

Controlling crystalline morphology of a bioabsorbable stent

Methods to expand polymer tubing with desirable or optimum morphology and mechanical properties for stent manufacture and fabrication of a stent therefrom are disclosed.

A method for screening fabric handle of an array of fabric samples (i.e., a plurality of fabric materials) comprising providing an array of at least two fabric samples, protruding the fabric samples through openings, and monitoring response of said fabric samples to the protrusions.

High throughput fabric handle screening

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San Jose, CA, United States of America

Mary Beth Kossuth