The Texas A&m University System

Marvin Xuejun Xu

Magnus A Hook

Elizabeth L Cosgriff-Hernandez

Neungseon Seo

Mariah S Hahn

Brooke Hageman Russell

Jose J Rivera

Mary Beth Monroe

Mary Beth Browning

The present disclosure provides synthetic collagen and methods of making and using synthetic collagen that include a synthetic collagen that facilitates wound closure comprising an isolated and purified triple helical backbone protein that facilitates wound closure comprising one or more alteration in a triple helical backbone protein sequence, that stabilize the isolated and purified triple helical backbone protein and does not disrupt an additional collagen ligand interaction; and one or more integrin binding motifs, wherein the isolated and purified triple helical backbone protein facilitates wound closure.

Designer collagens and use thereof

The present invention identified a recombinant synthetic collagen containing a triple helical backbone protein produced in a prokaryotic expression system where the protein contains at least one 'inserted' biologically active sequence(s).

Growing community of inventors

Missouri City, TX, United States of America

Marvin Xuejun Xu