Warner-lambert Company

Marvin P Cohen

John Shavel, Jr

Max Von Strandtmann

Sylvester R Klutchko

Maximilian Von Strandtmann

There is described 3-(1H-tetrazol-5-yl)chromones having the following structural formula: ##STR1## in which R is lower alkoxy having 1 to 3 carbon atoms, aryl such as phenyl, halogen or trihalo lower alkyl. These compounds exhibit anti-allergic properties and are indicated in the treatment of allergic conditions such as hay fever and asthma.

3-(1H-Tetrazol-5-yl)chromones

The present invention relates to [2-(4-oxo-4H-1-benzopyran-2-yl)ethenyl]benzonitrile and benzoic acids having the following structural formula: ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are hydrogen, lower alkyl, halogen or lower alkoxy, and A is COOH or CN. The compounds of this invention exhibit anti-allergy properties and are indicated in the management of allergic manifestations such as bronchial asthma.

[2-(4-Oxo-4H-1-benzopyran-2-yl)ethenyl]benzonitriles and benzoic acids

The present invention relates to substituted [4-oxo-4H-1-benzopyran-2-yl]cyclopropane carboxylic acids and esters having the following structural formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are hydrogen, alkyl, lower alkoxy, phenyl or when R.sub.1 and R.sub.2 are hydrogen, R.sub.3 and R.sub.4 taken together form an additional aromatic ring and A is hydrogen or ethyl. The compounds of this invention exhibit anti-allergy properties and are indicated in the management of allergic manifestations such as bronchial asthma.

Substituted (4-oxo-4H-1-benzopyran-2-yl)cyclopropane carboxylic acids

3-substituted cinnolinones having the following structural formula are disclosed: ##SPC1## Wherein R.sub.1 is hydrogen, lower alkyl, aralkyl or acyl and R.sub.2 and R.sub.3 are hydrogen, halogen, lower alkoxy or lower alkyl, and X is ##EQU1## CH.sub.3 COOCH.sub.2 S-, or ##SPC2## These compounds are useful as immunosuppressants.

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New Milford, NJ, United States of America

Marvin P Cohen