Celltech Therapeutics Limited

Martyn Kim Robinson

Raymond John Owens

This invention relates to whole antibodies of neutral isotype having specificity for E-selection, process for their preparation (using vectors), pharmaceutical compositions containing them, and their use in therapy (e.g. for inflammatory disorders) and diagnosis. Said antibodies are variants of natural antibodies altered in the F region, especially in the CH domain, so that the interactions with antibodies F receptors and complement are absent or very low.

Antibodies against E-selectin

This invention relates to whole antibodies of neutral isotype having specificity for E-selectin, process for their preparation (using vectors), pharmaceutical compositions containing them, and their use in therapy and diagnosis. Said antibodies are variants of natural antibodies altered in the F,region, especially in the CH,domain, so that the interactions with antibodies F,receptors and complement are very low.

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Penn, United Kingdom

Martyn Kim Robinson