Affinergy Inc.

Depuy Synthes Products, Inc.

Synthes USA, LLC

Synthes Gmbh

Martyn Kerry Darby

Shrikumar Ambujakshan Nair

Paul Theodore Hamilton

Hanne Gron

Isaac Gilliam Sanford

Yuchen Chen

Jonathan Allen Hodges

Ganesan Sathya

Michelle Steffen Jansen

Elliott A Gruskin

Danuta Wronska

Doug Buechter

R Edward Benson

Dalia Isolda Juzumiene

Natalia Lygina

Juhua Morrison

William David Culp

William Bourchier Siesser

Magdalena Krajewska

Isaac G Sanford

Cell binding peptides are provided for binding to cells including urothelial and thyroid follicular cells. The peptides are useful for detection and diagnosis of cancer including bladder and thyroid cancer. A device and method for using the device for capturing cells is provided, the device includes a support having attached cell binding peptide. The support can be a slide and the device can be used for detection and diagnosis of cancer including bladder and thyroid cancer. A kit is provided with instructions for capturing cells and a support with attached cell binding peptide for detection and diagnosis of bladder and thyroid cancer.

Cell binding peptides for diagnosis and detection

Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platelet derived growth factor (PDGF) binding peptides and growth differentiation factor (GDF) binding peptides. The tissue for repair includes tendon, muscle, connective tissue, ligament, cardiac tissue, vascular tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and growth factor binding peptides are attached, such as acellular extracellular matrix having attached binding peptide.

Methods and compositions for soft tissue repair

The presently disclosed subject matter relates to peptides having binding affinity for glycopeptide antibiotics and methods and compositions for delivering glycopeptide antibiotic to the surface of medical devices. The peptide compositions can comprise a peptide having binding affinity for a surface material of a medical device that is coupled to the peptide having binding affinity for glycopeptide antibiotic. Also provided are methods of applying the peptide compositions to a medical device by contacting the peptide compositions with a surface of the medical device. In addition, kits are provided comprising the peptide compositions.

Compositions and methods for delivery of glycopeptide antibiotics to medical device surfaces

Growing community of inventors

Chapel Hill, NC, United States of America

Martyn Kerry Darby