Critical Outcome Technologies Inc.

Other

Watson Laboratories Inc.

Martyn A Brown

Wayne Danter

Franck LePifre

Natalie Lazarowych

George Ma

Jianhua Zhong

Ghenadie Rusu

Stephen Houldsworth

Franck F Lepifre

Subakar Paramanantham

Valeriy Mikaylo

Ilya Avrutov

Zemin Li

Wayne R Danter

The present invention is directed to methods of use of a compound of Formula I: and/or a pharmaceutically-acceptable salt, hydrate, solvate, tautomer, optical isomer, or combination thereof, a composition comprising the thiosemicarbazone, a method of administration thereof, and use thereof to treat a cancer.

Compounds and method for treatment of cancer

An improved process is provided for the synthesis of hexahydrodibenzo[b,d]pyran-9-ones, such as nabilone.

Synthesis of hexahydrodibenzopyranones

The present invention relates to compounds of the Formula I, the pharmaceutically acceptable salts and stereoisomers thereof, which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions in mammals:  

Protein tyrosine kinase inhibitors

The present invention is directed to a compound of Formula I: and/or a pharmaceutically-acceptable salt, hydrate, solvate, tautomer, optical isomer, or combination thereof, a composition comprising the thiosemicarbazone, a method of administration thereof, and use thereof to treat a cancer.

The present invention relates to uses of the compounds of Formula I as well as pharmaceutically acceptable salts and stereoisomers thereof in methods to treat a variety of tumors in mammals involving abnormal tyrosine kinase signaling, the compounds represented as: 

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Toronto, Canada

Martyn A Brown