Duphar International Research Bv

Martinus Theodorus Maria Tulp

Cornelis G Kruse

Roelof W Feenstra

Stephen K Long

Wilma Kuipers

The invention relates to a group of new piperazine and piperidine compounds having interesting pharmacological properties. It has been found that compounds of formula (a) wherein A represents a heterocyclic group of 5-7 ring atoms wherein 1-3 heteroatoms from the group O, N and S are present; R,is hydrogen or fluoro; R,is C,-alkyl, C,-alkoxy or an oxo group, and p is 0, 1 or 2; Z represents carbon or nitrogen, and the dotted line is a single bond when Z is nitrogen, and a single or double bond when Z is carbon; R,and R,independently are hydrogen or C,-alkyl; n has the value 1 or 2; R,is halogen, hydroxy, C,-alkoxy or C,-alkyl, and q is 0, 1, 2 or 3; Y is phenyl, furanyl or thienyl, which groups may be substituted with 1-3 substituents of the group hydroxy, halogen, C,-alkoxy, C,-alkyl, cyano, aminocarbonyl, mono- or di-C,-alkylaminocarbonyl; and salts thereof show high affinity for both the dopamine D,and serotonin 5-HT,receptors.

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Weesp, Netherlands

Martinus Theodorus Maria Tulp