Duphar International Research Bv

Martinus T Tulp

Cornelis G Kruse

Ineke Van Wijngaarden

Jacobus A Den Hartog

Johannes A Van Der Heyden

Roelof W Feenstra

Stephen K Long

A group of new piperazine and piperidine compounds having interesting advantageous pharmacological properties and have the formula (a) ##STR1## wherein A represents a heterocyclic group having 5-7 ring atoms wherein 1-3 heteroatoms selected from the group O, N and S are present,

Piperazine and piperidine compounds

The invention relates to a group of tertiary 2,5-dialkyl-3-phenylpiperidine derivatives, having opiate-antagonistic activity represented by general formula 4, ##STR1## wherein A.sub.1 is hydrogen, an optionally esterified hydroxyl group or mercapto group, a group NHA.sub.8 or --CONHA.sub.8, wherein A.sub.8 is hydrogen, alkyl having 1-6 C-atoms or alkylcarbonyl having 2-7 C-atoms;

Tertiary 2,5-dialkyl-3-phenylpiperidine derivatives having

The invention relates to new aryl-substituted (N-piperidinyl)methyl- and (N-piperazinyl)methylazoles having interesting pharmacological, notably antipsychotic, properties. The compounds may be prepared in a manner known for the synthesis of analogous compounds and be processed to compositions according to known methods.

Aryl-substituted (N-piperidinyl)methyl- and (N-piperidinyl) methylazoles

Phenyl-substituted (N-piperazinyl) methylazoles for treating affections

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Weesp, Netherlands

Martinus T Tulp