Biolipox Ab

Roche Innovation Center Copenhagen A/s

Martins Katkevics

Benjamin Pelcman

Ivars Kalvins

Edgars Suna

Vita Ozola

Dace Katkevica

Kristofer Olofsson

Erik Daa Funder

Nanna Albaek

Peteris Trapencieris

Wesley Schaal

The present invention relates to an optimized method for preparing a P(V) monomer of formula (IIIa) or (IIIb) from a nucleoside using DBU as a base at about 0.8 equivalent to nucleoside.

Process for preparing nucleotide P(V) monomers

 There is provided compounds of formula (I), wherein X, Q, T, Y, R, R, R, Rand Rhave meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a member of the MAPEG family is desired and/or required, and particularly in the treatment of inflammation.

Indoles useful in the treatment of inflammation

There is provided a compound of formula: (I), wherein X, R, R, R, R, Rand Rhave meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of microsomal prostaglandin E synthase-1 is desired and/or required, and particularly in the treatment of inflammation. 

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Riga, Latvia

Martins Katkevics