Novartis Vaccines and Diagnostics Srl

Consiglio Nazionale Delle Ricerche

Katholieke Universiteit Leuven, Ku Leuven R&d

Aix-Marseille Université

Cisi Scrl

Martino Bolognesi

Guido Grandi

Eloise Mastrangelo

Johan Neyts

Carlo Scolastico

Suzanne Kaptein

Leonardo Manzoni

Pierfausto Seneci

Laura Belvisi

Domenico Delia

Carmelo Drago

Mario Milani De Mayo De Mari

Boris Pastorino

Mario De Mayo De Mari Milani

Ilaria Motto

Avermectin and milbemycin compounds, particularly the substance ivermectin, for preparing an antiviral medicament for the treatment, prevention or amelioration of ainfection, such as those caused by YFV (yellow fever virus), DENV (Dengue virus), JEV (Japanese encephalitis virus), TBEV (tick-borne encephalitis virus) or MODV (Modoc virus) are provided. The antiviral compositions of the present invention are suitable for oral administration to a-infected subject or a subject at risk of a infection, such as a human or other mammal.

Avermectins and milbemycins for the treatment, prevention or amelioration of flavivirus infections

The present invention relates to compounds conformationally constrained mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of apoptotic cell death is beneficial, especially in the treatment of cancer, alone or in combination with other active ingredients.

SMAC mimetic compounds as apoptosis inducers

The extracellular loop of CD81 is a cellular receptor for the E2 protein of hepatitis C virus. A CD81 crystal structure has been elucidated and is provided for use in the structure-based design of compounds which bind to CD81 and thus block the binding of HCV. Methods such as docking and de novodrug design can be used.

Structure-based hepatitis C virus drug design

Tetraspanins have been found to dimerise. Methods for inhibiting or promoting the dimerisation of tetraspanins are provided, which may involve protein engineering of the tetraspanins themselves, or may rely on other molecules.

Modulation of tetraspanin function

Growing community of inventors

Torre d'Isola, Italy

Martino Bolognesi