Institut National De La Sante Et De La Recherche Medicale

Université´ D'aix-marseille

Other

Centre National De La Recherche Scientifique

Universitè De Montpellier

Assistance Publique Hopitaux De Marseille

Institut Regional Du Cancer De Montpellier-val D'aurelle

Institut Paoli Calmettes

Inserm

Martine Mansais

Daniel Baty

Patrick Chames

Brigitte Kerfelec

Caroline Rozan

Andre Pelegrin

Jean-luc Teillaud

Isabelle Teulon

Ghislaine Behar

The invention concerns antibody formats comprising VH sequence of Camelidae, such as llamas; antibodies of various formats have anti-CEA or anti-CD16 VH sequences thereof; vectors expressing the antibody formats, and methods for producing the same.

Production of antibody formats and immunological applications of said formats

The present invention relates to antigen binding formats for use in therapeutic treatments or diagnostic assays. The present invention relates to an antigen-binding format consisting of: &#x2014;a first fusion protein wherein the CH1 constant domain of an antibody is fused i) by its N-terminal end to the C-terminal end of a variable domain of an antibody and ii) by its C-terminal end to the N-terminal end of a variable domain of an antibody and, &#x2014;a second fusion protein wherein the CL constant domain of an antibody is fused by its N-terminal end to the C-terminal end of a variable domain of an antibody.

Antigen binding formats for use in therapeutic treatments or diagnostic assays

Growing community of inventors

Marseilles, France

Martine Mansais