Transgene S.a.

Martine Baudin

Nathalie Silvestre

Jean-Marc Balloul

A nucleic acid molecule encoding at least one papillomavirus E2 polypeptide, or a vector, an infectious viral particle or a therapeutic composition thereof is formulated into a drug product useful for treating a patient suffering from a persistent papillomavirus infection caused by at least one papillomavirus; particular such vectors are nucleic acid molecules containing a first nucleotide sequence encoding a papillomavirus E1 polypeptide and a second nucleotide sequence encoding a papillomavirus E2 polypeptide wherein the 3' portion of the first nucleotide which in the natural content is 100% identical to the 5&#x2032; portion of the second nucleotide is modified so as to exhibit a percentage of identity between said portions of at most 75%.

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Caluire, France

Martine Baudin