Boehringer Ingelheim Vetmedica Gmbh

Martina Von Freyburg

Knut Elbers

Gregor Meyers

Marika Christine Genzow

Carola Kissel

Luc-Etienne Fabry

Christiane Fetzer

William Charles Ohnesorge

Kathleen Kwan Young Park

Isabelle Freiin Von Richthofen

Wiliam Charles Ohnesorge

Kathleen Park

Andreas Ege

Christiane Meyer

The present invention provides a one phase, aqueous vaccine composition for immunizing an animal against infection by, comprising: an immunizing amount of abacterin, an acrylic acid polymer in the concentration range between 0.8 and 1.2 mg/ml, and a pharmaceutically acceptable carrier, and substantially no oil. It is especially useful for immunizing a pig against infection byfor at least 20 weeks after a single administration, which effective immunity is reached within 4 weeks after vaccination.

One dose vaccination against mycoplasma infections of pigs

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The invention belongs to the field of animal health and in particular Bovine Viral Diarrhea Virus (BVDV). The invention provides infectious BVDV clones and methods to produce said BVDV clones. The invention further relates to methods of attenuating said clones, attenuated BVDV clones and vaccines comprising said attenuated clones.

Infectious bovine viral diarrhea virus

Attenuated pestiviruses, in particular attenuated BVDV, wherein at least one mutation is in the coding sequence for glycoprotein Eand at least another mutation in the coding sequence for Nwhich preferably leads to combined inactivation of the RNase activity residing in glycoprotein Ein addition to the inactivation of the (hypothesized) immunomodulating activity residing in N. Methods for attenuating pestiviruses such as BVDV, nucleic acids encoding the pestiviruses, in particular BVDV, compositions and vaccines comprising the attenuated pestiviruses, in particular BVDV, of the invention.

Vaccine comprising an attenuated pestivirus

Infectious bovine viral diarrhea virus clone

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Mainz, Germany

Martina Von Freyburg