Abbott Gmbh & Co Kg

Gilead Colorado, Inc.

Martina Ullrich

Hans-Guenther Hege

Andreas Kling

Andreas Haupt

Wilhelm Amberg

Thomas Zierke

Ernst Buschmann

Bernd Janssen

Kurt Ritter

Teresa Barlozzari

Harald Bernard

Helmut Lietz

Jurgen Weymann

Lawrence S Melvin, Jr

Jürgen Weymann

Jurgen Weyman

The present invention provides antineoplastic peptides of formula I, wherein R, R, X, A, B, D, E, G, K and s have the meanings stated in the description. The compounds have antineoplastic activity.

Antineoplastic peptides

The invention relates to derivatives and metabolites of ambrisentan, including compounds of general Formula (I) or salts, hydrates, solvates, racemates, or optical isomers thereof, wherein Ris &#x2014;OH or &#x2014;OCH; Ris &#x2014;H, lower alkyl (e.g. C-Calkyl) or glycosidyl; and Rand Rare independently &#x2014;CH, &#x2014;C(O)H or &#x2014;CHOR, wherein Ris &#x2014;H or a hydrocarbyl group having 1 to 20 carbon atoms.

Metabolites and derivatives of ambrisentan

The present invention provides antineoplastic peptides of formula I,RRN&#x2014;CHX&#x2014;CO&#x2014;A&#x2014;B-D-E-(G)-Kwherein R, R, X, A, B, D, E, G, K and s have the meanings stated in the description. The compounds have antineoplastic activity.

The present invention provides antineoplastic peptides of formula I,RRN&#x2014;CHX&#x2014;CO-A-B-D-E-(G)-K Iwherein R, R, X, A, B, D, E, G, K, and s have the meanings stated in the description. The compounds have antineoplastic activity.

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Schrieshaim, Germany

Martina Ullrich